In the past twenty years hundreds of infants and young children have died after being left in vehicles, usually by accident. When turning the vehicle off, drivers of the RX are reminded to check the back seat if they opened the rear door before starting out. The Cayenne doesn’t offer a back seat reminder.
The RX’s driver alert monitor detects an inattentive driver then sounds a warning and suggests a break. According to the NHTSA, drivers who fall asleep cause about 100,000 crashes and 1500 deaths a year. The Cayenne doesn’t offer a driver alert monitor.
Both the RX and the Cayenne have standard driver and passenger frontal airbags, front and rear side-impact airbags, driver and front passenger knee airbags, side-impact head airbags, height adjustable front shoulder belts, four-wheel antilock brakes, traction control, electronic stability systems to prevent skidding, crash mitigating brakes, post-collision automatic braking systems, daytime running lights, lane departure warning systems, blind spot warning systems, rearview cameras, rear cross-path warning, available all wheel drive and around view monitors.
The Lexus RX achieved a “Top Safety Pick” rating from the Insurance Institute for Highway Safety (IIHS) for the 2024 model year. This recognition was based on its impressive performance in the small overlap frontal crash test, updated side impact crash test, headlight evaluations, and pedestrian crash prevention testing. The Cayenne has not yet been evaluated by the IIHS for 2024.

